Fig. 4

Endpoint therapeutic effects on proliferation, tumor vascularity, and apoptosis. a Ki67 for proliferation index was scored by positive counts per core section and plotted as mean percent positive ± standard deviation with no change observed at endpoint. b CD31 for blood vessel density was scored by positive pixel count over area and plotted as mean percent ± standard deviation, only erlotonib had a significant change observed at endpoint (P = 0.44). c Cleaved caspase-3 (CC3) for apoptotic index was scored by positive pixel count over area and plotted as mean percent ± standard deviation. Oxaliplatin treatment yielded significant apoptosis (P = 0.0109) compared to placebo. d Representative CC3 IHC was shown for placebo and oxaliplatin groups. Asterisk indicated P < 0.05 for treatment group as compared to placebo, n = 5