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Table 4 Hazard ratios of SUA levels for incidence hypertension during 6 years of follow-up among 3591subjects without hypertension at the entyry examination

From: Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study

Model N (%) Hazard ratio 95 % CI P-value
Baseline values: models 1–3
Model 1: unadjusted baseline values of variables
 Quartile 1 903 (25.1 %) 0.000
 Quartile 2 886 (24.7 %) 1.652 1.265–2.156 0.000
 Quartile 3 905 (25.2 %) 2.195 1.705–2.825 0.000
 Quartile 4 897 (25.0 %) 3.058 2.399–3.899 0.000
 SUA as a continuous variable (μmol/L) 3591 2.039 1.747–2.379 0.000
Model 2: model 1 adjusted for age and gender
 Quartile 1 0.000
 Quartile 2 1.644 1.253–2.158 0.000
 Quartile 3 2.274 1.746–2.963 0.000
 Quartile 4 3.174 2.448–4.114 0.000
 SUA as a continuous variable (μmol/L) 1.703 1.292–2.243 0.000
Model 3: model 2 further adjusted for other confounders
 Quartile 1 0.000
 Quartile 2 1.754 1.321–2.328 0.000
 Quartile 3 2.349 1.774–3.111 0.000
 Quartile 4 3.152 2.371–4.191 0.000
 SUA as a continuous variable (μmol/L) 1.793 1.512–2.126 0.000
Follow-up values: models 4–6
Model 4: unadjusted follow-up values of variables
 Quartile 1 897 (25.0 %) 0.018
 Quartile 2 878 (24.5 %) 1.279 1.029–1.590 0.027
 Quartile 3 917(25.5 %) 1.160 0.886–1.519 0.281
 Quartile 4 899(25.0 %) 1.366 1.120–1.666 0.002*
 SUA as a continuous variable (μmol/L) 3591 1.104 1.030–1.184 0.005*
Model 5: model 4 adjusted for age and sex
 Quartile 1 0.009*
 Quartile 2 1.243 1.060–1.639 0.013*
 Quartile 3 1.410 0.947–1.630 0.117
 Quartile 4 1.264 1.155–1.722 0.001*
 SUA as a continuous variable (μmol/L) 1.264 1.198–1.335 0.000
Model 6: model 5 further adjusted for other confounders
 Quartile 1 0.026*
 Quartile 2 1.103 1.031–1.179 0.004*
 Quartile 3 1.043 0.778–1.398 0.780
 Quartile 4 1.350 1.106–1.648 0.003*
 SUA as a continuous variable (μmol/L) 1.157 1.066–1.255 0.001*
  1. Model 1–3 (Baseline) Quartiles based on serum uric acid levels: 1, <4.69 mg/dl; 2, 4.69–5.58 mg/dl; 3, 5.58–6.52 mg/dl; 4, ≥6.52 mg/dl
  2. Model 4–6 (Means during follow-up period) Quartiles based on serum uric acid levels: 1, <4.64 mg/dl; 2, 4.64–5.41 mg/dl; 3, 5.41–5.78 mg/dl; 4, ≥5.78 mg/dl
  3. Model 3 was further adjusted for BMI, triglycerides, eGFR, blood urea nitrogen, serum creatinine, plasma total protein, globulin, alanine aminotransferase, and direct bilirubin
  4. Model 6 was further adjusted for BMI, triglycerides, total cholesterol, high-density lipoproteins, estimated glomerular filtration rate, blood urea nitrogen, serum creatinine, fasting plasma glucose, plasma total protein, globulin, albumin, alanine aminotransferase, total bilirubin, and direct bilirubin
  5. * P < 0.05 was considered statistically significant