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Table 4 Hazard ratios of SUA levels for incidence hypertension during 6 years of follow-up among 3591subjects without hypertension at the entyry examination

From: Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study

Model

N (%)

Hazard ratio

95 % CI

P-value

Baseline values: models 1–3

Model 1: unadjusted baseline values of variables

 Quartile 1

903 (25.1 %)

–

–

0.000

 Quartile 2

886 (24.7 %)

1.652

1.265–2.156

0.000

 Quartile 3

905 (25.2 %)

2.195

1.705–2.825

0.000

 Quartile 4

897 (25.0 %)

3.058

2.399–3.899

0.000

 SUA as a continuous variable (μmol/L)

3591

2.039

1.747–2.379

0.000

Model 2: model 1 adjusted for age and gender

 Quartile 1

–

–

–

0.000

 Quartile 2

–

1.644

1.253–2.158

0.000

 Quartile 3

–

2.274

1.746–2.963

0.000

 Quartile 4

–

3.174

2.448–4.114

0.000

 SUA as a continuous variable (μmol/L)

–

1.703

1.292–2.243

0.000

Model 3: model 2 further adjusted for other confounders

 Quartile 1

–

–

–

0.000

 Quartile 2

–

1.754

1.321–2.328

0.000

 Quartile 3

–

2.349

1.774–3.111

0.000

 Quartile 4

–

3.152

2.371–4.191

0.000

 SUA as a continuous variable (μmol/L)

–

1.793

1.512–2.126

0.000

Follow-up values: models 4–6

Model 4: unadjusted follow-up values of variables

 Quartile 1

897 (25.0 %)

–

–

0.018

 Quartile 2

878 (24.5 %)

1.279

1.029–1.590

0.027

 Quartile 3

917(25.5 %)

1.160

0.886–1.519

0.281

 Quartile 4

899(25.0 %)

1.366

1.120–1.666

0.002*

 SUA as a continuous variable (μmol/L)

3591

1.104

1.030–1.184

0.005*

Model 5: model 4 adjusted for age and sex

 Quartile 1

–

–

–

0.009*

 Quartile 2

–

1.243

1.060–1.639

0.013*

 Quartile 3

–

1.410

0.947–1.630

0.117

 Quartile 4

–

1.264

1.155–1.722

0.001*

 SUA as a continuous variable (μmol/L)

–

1.264

1.198–1.335

0.000

Model 6: model 5 further adjusted for other confounders

 Quartile 1

–

–

–

0.026*

 Quartile 2

–

1.103

1.031–1.179

0.004*

 Quartile 3

–

1.043

0.778–1.398

0.780

 Quartile 4

–

1.350

1.106–1.648

0.003*

 SUA as a continuous variable (μmol/L)

–

1.157

1.066–1.255

0.001*

  1. Model 1–3 (Baseline) Quartiles based on serum uric acid levels: 1, <4.69 mg/dl; 2, 4.69–5.58 mg/dl; 3, 5.58–6.52 mg/dl; 4, ≥6.52 mg/dl
  2. Model 4–6 (Means during follow-up period) Quartiles based on serum uric acid levels: 1, <4.64 mg/dl; 2, 4.64–5.41 mg/dl; 3, 5.41–5.78 mg/dl; 4, ≥5.78 mg/dl
  3. Model 3 was further adjusted for BMI, triglycerides, eGFR, blood urea nitrogen, serum creatinine, plasma total protein, globulin, alanine aminotransferase, and direct bilirubin
  4. Model 6 was further adjusted for BMI, triglycerides, total cholesterol, high-density lipoproteins, estimated glomerular filtration rate, blood urea nitrogen, serum creatinine, fasting plasma glucose, plasma total protein, globulin, albumin, alanine aminotransferase, total bilirubin, and direct bilirubin
  5. * P < 0.05 was considered statistically significant
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Journal of Translational Medicine

ISSN: 1479-5876

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