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Table 4 Specific genetic alterations in TP53 gene detected in the five SCLC PDXs

From: Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer

PDX TP53 alteration COSMIC ID# Remarks
TKO-001 c.422G>A[p.Cys141Tyr] COSM131470 Missense mutation
TKO-002 c.488A>G[p.Tyr163Cys] COSM10808 Listed in COSMIC and dbSNP (rs148924904), evidence in COSMIC for being somatic
TKO-003 c.913A>T[p.Lys305Ter] COSM43773 Stop (Ter) Hemizygous, deletion of one copy
TKO-005 c.488A>G[p.Tyr163Cys] COSM10808 Listed in COSMIC and dbSNP (rs148924904), evidence in COSMIC for being somatic
TKO-008 c.892G>T[p.Glu298Ter] COSM10710 Stop (Ter) 80 % of reads