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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

Fig. 5

Autophagy and cardiac apoptosis in rats in the control, diabetes mellitus (DM), and diabetes + trimetazidine (DM + TMZ) groups. a Representative images and analysis of the TUNEL assay (scale bar 20 μm). b Representative western blot bands and analysis of C-Caspase 3/β-actin and C-PARP/β-actin. c Representative western blot bands and analysis of LC3-II/LC3-I. d Representative western blot bands and analysis of ATG5/β-actin and ATG7/β-actin. Data are mean ± SEM. ATG, autophagy [protein]. C-PARP, C–poly (ADP-ribose) polymerase. LC3, light chain 3 [protein]. TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling. *p < 0.05 compared with control group; and # p < 0.05 compared with diabetes group

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Journal of Translational Medicine

ISSN: 1479-5876

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