Table 3 Pharmacokinetic analysis of erlotinib in Schedule A patients

Erlotinib alone (day 6)

 AUC (μM)

23.45

29.68

45.44

46.19

13.87

50.14

 Cmax (μM)

2.17

1.83

2.73

2.97

0.86

3.42

 Tmax (h)

6

6

8

8

8

8

 t _1/2 (h)

7.1

25.7

18.1

15.1

15.4

9.4

Erlotinib (+rosuvastatin) (day 14)

 AUC (μM)

off study

34.32

62.74

59.51

21.22

24.81

 Cmax (μM)

off study

1.96

3.95

3.90

1.19

1.57

 Tmax (h)

off study

8

6

10

10

8

 t_1/2 (h)

off study

24.3

14.5

12.8

12.8

13.3