Table 1 Patient characteristics
| Â | Concurrent Cohorts 1 and 2/Schedule A | Alternating Schedule B | All patients |
|---|---|---|---|
Number of patients | 18 | 6 | 24 |
Age (years) | |||
 Median/range | 60/43–70 | 54/44–63 | 58/43–70 |
Gender | |||
 Male | 11 (60 %) | 4 (67 %) | 15 (63 %) |
 Female | 7 (40 %) | 2 (33 %) | 9 (37 %) |
Ethnicity | |||
 Caucasian |  |  | 23 (96 %) |
 Other |  |  | 1 (4 %) |
Primary tumour | |||
 NSCLC | 5 | 2 | 7 |
 Esophageal | 4 |  | 4 |
 Pancreas | 2 | 1 | 3 |
 GU | 4 | 2 | 6 |
 Colon | 2 |  | 2 |
 Breast | 1 |  | 1 |
 Unknown |  | 1 | 1 |
Number | Frequency | Percent |
|---|---|---|
Previous treatment regimens | ||
 1 | 7 | 29.2 |
 2 | 8 | 33.3 |
 3 | 6 | 25.0 |
 >3 | 3 | 12.5 |
Reason Off protocol | ||
 Progressive disease | 19 | 79.2 |
 Adverse event | 1 | 4.2 |
 Patient withdrawal | 2 | 8.3 |
 Other | 2 | 8.3 |