|
A. Four sample subsets defined by Miettinen risk score (Fig. 3a, p < 0.001)
|
|
High risk, n = 17
|
0.53 (0.34–0.83)
|
0.28 (0.12–0.68)
|
0.28 (0.12–0.68)
|
0.28 (0.12–0.68)
|
3.4 (1.1, 10.9)
|
|
Intermediate risk, n = 14
|
0.93 (0.80–1.00)
|
0.85 (0.68–1.00)
|
0.68 (0.42–1.00)
|
0.68 (0.42–1.00)
|
Reference group
|
|
Low risk, n = 16
|
NR
|
NR
|
NR
|
No follow-up
|
Not estimable
|
|
Very low risk, n = 13
|
NR
|
NR
|
NR
|
NR
|
Not estimable
|
|
B. Two sample subsets among the high- and intermediate-risk samples defined by the AF-gene set in Fig. 1a (Fig. 3b, p = 0.01)
|
|
Good group, n = 8
|
NR
|
NR
|
No follow-up
|
No follow-up
|
Reference group
|
|
Bad group, n = 23
|
0.61 (0.44–0.85)
|
0.39 (0.22–0.68)
|
0.32 (0.17–0.63)
|
0.32 (0.17–0.63)
|
Not estimable
|
|
C. Two sample subsets among the high- and intermediate-risk samples defined by the OVCA-gene set in Fig. 1B (Fig. 3C, p < 0.001)
|
|
Good group, n = 14
|
NR
|
0.93 (0.80–1.00)
|
0.93 (0.80–1.00)
|
0.93 (0.80–1.00)
|
Reference group
|
|
Bad group, n = 17
|
0.47 (0.28-0.78)
|
0.20 (0.06–0.63)
|
0.10 (0.02–0.61)
|
0.10 (0.02–0.61)
|
19.9 (2.6–154.0)
|
|
D. Two sample subsets among the high- and intermediate-risk samples defined by the RCC-gene set in Fig. 1c (Fig. 3d, p = 0.045)
|
|
Good group, n = 17
|
0.59 (0.40–0.88)
|
0.38 (0.20–0.72)
|
0.28 (0.12–0.67)
|
0.28 (0.12–0.67)
|
3.4 (1.0, 12.3)
|
|
Bad group, n = 14
|
0.86 (0.69–1.00)
|
0.78 (0.59–1.00)
|
No follow-up
|
No follow-up
|
Reference group
|
|
E. Two sample subsets among the high- and intermediate-risk samples defined by the combined gene set in Fig. 1d (Fig. 3e, p = 0.06129).
|
|
Good group, n = 5
|
NR
|
NR
|
No follow-up
|
No follow-up
|
Reference group
|
|
Bad group, n = 26
|
0.65 (0.49–0.87)
|
0.46 (0.29–0.72)
|
0.38 (0.21–0.68)
|
0.38 (0.21–0.68)
|
Not estimable
|
