Fig. 1
MSC infusion promotes survival, improves gross and microscopic histopathology in TAA-induced FHF. a MSC treatment substantially improved the gross histopathological appearance of TAA-stimulated livers with reduction of extravasated blood. Asterisk marks the changes occurred to liver 24 h after MSC infusion. b Kaplan–Meier survival analysis of mice with TAA-induced FHF. c Flow cytometry analysis of macrophages. d HE staining e F4/80 immunohistochemistry f CD45+ immunofluorescence staining of livers sections from control and MSC-treated mice demonstrated a massive reduction of leukocyte and macrophage infiltration. Data are shown as mean ± standard error of the mean of 10 random high-power fields per mouse. *P < 0.05; **P < 0.01; ***P < 0.001