The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women

Table 4 Multiple linear regression analysis for the association between ALT (independent variable) and BMD and bone metabolic parameters (dependent variables) in different models (Men)

	Model 1		Model 2		Model 3		Model 4
	Std β	P	Std β	P	Std β	P	Std β	P
Men
Lumbar spine BMD	−0.102	0.005	−0.120	0.001	−0.120	0.001	−0.142	<0.001
Hip BMD	−0.075	0.041	−0.062	0.105	−0.056	0.151	−0.073	0.046
Whole-body BMD	−0.164	<0.001	−0.152	<0.001	−0.118	0.001	−0.143	<0.001
25(OH)D	0.012	0.747	0.017	0.647	−0.018	0.638	–	–
Osteocalcin	−0.093	0.012	−0.085	0.019	−0.102	0.006	–	–
β-CTX	0.001	0.994	0.001	0.981	0.002	0.952	–	–

Model 1 included liver fat content, age and body weight
Model 2 included liver fat content, age, body weight, alcohol drinking, cigarrete smoking, anti-osteporotic drug use, SBP, FBG, triglyceride, cholesterol, and uric acid
Model 3 included liver fat content, age, body weight, alcohol drinking, cigarrete smoking, SBP, FBG, triglyceride, cholesterol, HDL-c,uric acid, body fat percentage, and trunk to appendicular fat ratio
Model 4 included same as model 3 plus serum 25(OH)D, osteocalcin, andβ-CTx levels
Std β denotes standardized β coefficient, BMD bone mineral density, 25(OH)VitD 25-hydroxyvitamin D, β-CTx β-isomerized form carboxy-terminal telopeptide of type I collagen, SBP systolic blood pressure, FBG fasting blood glucose, HDL-c high-density lipoprotein-cholesterol

ISSN: 1479-5876