The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women

Table 3 Multiple linear regression analysis for the association between liver fat content (independent variable) and BMD and bone metabolic parameters (dependent variables) in different models

	Model 1		Model 2		Model 3		Model 4
	Std β	P	Std β	P	Std β	P	Std β	P
Men
Lumbar spine BMD	−0.116	0.003	−0.111	0.003	−0.111	0.003	−0.123	0.001
Hip BMD	−0.095	0.014	−0.101	0.007	−0.092	0.017	−0.101	0.008
Whole-body BMD	−0.134	<0.001	−0.122	0.001	−0.123	0.001	−0.130	<0.001
25(OH)D	−0.073	0.044	−0.027	0.457	−0.018	0.638	–	–
Osteocalcin	−0.183	<0.001	−0.133	<0.001	−0.116	0.001	–	–
β-CTx	0.014	0.715	0.015	0.694	0.023	0.560	–	–
Postmenopausal women
Lumbar spine BMD	−0.093	0.008	−0.086	0.015	−0.056	0.116	−0.068	0.068
Hip BMD	−0.034	0.331	−0.044	0.215	−0.015	0.689	−0.029	0.429
Whole-body BMD	−0.107	0.002	−0.072	0.041	−0.023	0.510	−0.041	0.224
25(OH)D	0.027	0.410	0.034	0.332	0.044	0.223	–	–
Osteocalcin	−0.060	0.099	−0.046	0.197	−0.025	0.498	–	–
β-CTx	−0.035	0.298	−0.029	0.384	−0.021	0.563	–	–

Model 1 included liver fat content, age and body weight
Model 2 included liver fat content, age, body weight, alcohol drinking, cigarrete smoking, anti-osteporotic drug use, SBP, FBG, triglyceride, cholesterol, and uric acid
Model 3 included liver fat content, age, body weight, alcohol drinking, cigarrete smoking, SBP, FBG, triglyceride, cholesterol, HDL-c,uric acid, body fat percentage, and trunk to appendicular fat ratio
Model 4 included same as model 3 plus serum 25(OH)D, osteocalcin, and β-CTx levels
Std β denotes standardized β coefficient, BMD bone mineral density, 25(OH)VitD 25-hydroxyvitamin D, β-CTx β-isomerized form carboxy-terminal telopeptide of type I collagen, SBP systolic blood pressure, FBG fasting blood glucose, HDL-c high-density lipoprotein-cholesterol

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