Fig. 8

Changes in isoform phosphorylation of the target signaling protein, MEK1/2, in response to ischemia. An overview of ischemia-dependent regulation of isoforms of MEK1/2 in normal tissue of all patients analyzed is shown in a. Corresponding data for tumor tissue are shown in b. Results were displayed as fold changes normalized to sample NC5/N0 and in tumor tissue to sample NC5/T0. Kruskal–Wallis test and Dunn test for multiple comparisons were used for statistical analysis. N normal tissue, T tumor tissue, 0 before surgery, 10, 20, 45 10, 20, 45 min after resection; time points (10, 20, 45) are compared to time point 0; ^a p ≤ 0.05; ^b p ≤ 0.01; ^c p ≤ 0.001