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Table 1 Common immunoreactive proteins identified by CC sera in at least one-third of sera with the different antigenic extracts used

From: Autoantibody signatures defined by serological proteome analysis in sera from patients with cholangiocarcinoma

Proteins

Access number

CCSW1

CCLP1

Tumour tissue

Adjacent non-tumour tissue

Normal liver

3-Ketoacyl-CoA thiolase

P42765

NI

NI

NI

2/5 (40 %)

6/13 (46 %)

78 kDa glucose regulated protein

P11021

NI

5/13 (38 %)

NI

I

NI

α-Enolase

P06733

NI

NI

3/5 (60 %)

2/5 (40 %)

NI

β-Enolase

P13929

NI

NI

NI

2/5 (40 %)

NI

Acetyl coA acetyl transferase

P24752

NI

NI

NI

2/5 (40 %)

4/13 (31 %)

Aconitate hydratase

Q99798

NI

NI

NI

NI

5/13 (38 %)

Actin

P60709

4/13 (31 %)

6/13 (46 %)

4/5 (80 %)

I

NI

Aldehyde dehydrogenase

F8W0A9

NI

NI

NI

NI

4/13 (31 %)

Annexin A1

P04083

NI

6/13 (46 %)

I

NI

NI

Annexin A2

P07355

8/13 (62 %)

9/13 (69 %)

2/5 (40 %)

I

NI

Annexin A4

P09525

NI

NI

2/5 (40 %)

NI

NI

Annexin A5

P08758

NI

NI

2/5 (40 %)

NI

NI

ATP bifunctional dihydroxyacetone kinase

Q3LXA3

NI

NI

NI

I

5/13 (38 %)

ATP synthase sub unit α

P25705

NI

NI

3/5 (60 %)

NI

NI

ATP synthase sub unit β

P06576

NI

NI

I

2/5 (40 %)

NI

Carbonic anhydrase 1

P00915

NI

NI

I

NI

4/13 (31 %)

Catalase

P04040

NI

NI

NI

2/5 (40 %)

NI

∆(3,5)-∆(2,4)-dienoyl-CoA isomerase

Q13011

NI

NI

I

I

4/13 (31 %)

∆-1-pyrroline-5-carboxylate dehydrogenase

P30038

NI

NI

NI

NI

4/13 (31 %)

Dihydrolipoyl dehydrogenase

P09622

6/13 (46 %)

NI

I

I

NI

Electron transfer flavoprotein α

P13804

NI

NI

NI

NI

5/13 (38 %)

Epoxyde hydrolase

P07099

NI

NI

NI

2/5

(40 %)

NI

Estradiol 17-β-dehydrogenase 8

Q92506

NI

NI

NI

NI

5/13 (38 %)

Fructose-1.6-biphosphatase 1

P09467

NI

NI

NI

I

5/13 (38 %)

Fructose biphosphate aldolase A

P04075

NI

5/13 (38 %)

NI

NI

NI

Fructose biphosphate aldolase B

P05062

NI

NI

NI

4/5 (80 %)

5/13 (38 %)

Glutathione S-transferase

P09211

NI

4/13 (31 %)

NI

NI

NI

Glyceraldehyde-3-phosphate dehydrogenase

E7EUT4

NI

NI

I

I

7/13 (54 %)

hnRNP C1/C2

G3V4C1

4/13 (31 %)

NI

NI

NI

NI

hnRNP K

P61978

4/13 (31 %)

NI

NI

NI

NI

hnRNP L

P14866

7/13 (54 %)

NI

NI

NI

NI

HSP1 β1

P04792

NI

7/13 (54 %)

I

NI

NI

HSP 60

P10809

4/13 (31 %)

NI

NI

3/5 (60 %)

NI

Lamin B2

Q03252

NI

5/13 (38 %)

NI

NI

NI

Liver arginase (arginase 1)

P05089

NI

NI

NI

2/5 (40 %)

7/13 (54 %)

Liver carboxyl-esterase 1

E9PAU8

NI

NI

NI

2/5 (40 %)

NI

Prelamine A/C

P02545

P02545-2

9/13 (69 %)

NI

I

3/5 (60 %)

4/13 (31 %)

Proteasome su α2

P25787

G3V295

NI

NI

2/5 (40 %)

NI

NI

Protein phosphatase 1

Q15435

4/13 (31 %)

NI

NI

NI

NI

Retinal dehydrogenase 1

P00352

NI

4/13 (31 %)

I

2/5 (40 %)

NI

Serine hydroxymethyltransferase

P34896

NI

5/13 (38 %)

NI

NI

NI

Serotransferrin

P02787

NI

NI

5/5 (100 %)

I

NI

Serum albumin

P02768

NI

NI

2/5 (40 %)

3/5 (60 %)

NI

S-methyl-5′ thioadenosine phosphorylase

Q13126

NI

NI

NI

NI

5/13 (38 %)

Vimentin

P08670

13/13 (100 %)

4/13 (31 %)

I

NI

NI

  1. NI not identified, I recognized by less than 31 % of CC sera. Access numbers are from the Swiss-Prot database