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Table 1 Common immunoreactive proteins identified by CC sera in at least one-third of sera with the different antigenic extracts used

From: Autoantibody signatures defined by serological proteome analysis in sera from patients with cholangiocarcinoma

Proteins Access number CCSW1 CCLP1 Tumour tissue Adjacent non-tumour tissue Normal liver
3-Ketoacyl-CoA thiolase P42765 NI NI NI 2/5 (40 %) 6/13 (46 %)
78 kDa glucose regulated protein P11021 NI 5/13 (38 %) NI I NI
α-Enolase P06733 NI NI 3/5 (60 %) 2/5 (40 %) NI
β-Enolase P13929 NI NI NI 2/5 (40 %) NI
Acetyl coA acetyl transferase P24752 NI NI NI 2/5 (40 %) 4/13 (31 %)
Aconitate hydratase Q99798 NI NI NI NI 5/13 (38 %)
Actin P60709 4/13 (31 %) 6/13 (46 %) 4/5 (80 %) I NI
Aldehyde dehydrogenase F8W0A9 NI NI NI NI 4/13 (31 %)
Annexin A1 P04083 NI 6/13 (46 %) I NI NI
Annexin A2 P07355 8/13 (62 %) 9/13 (69 %) 2/5 (40 %) I NI
Annexin A4 P09525 NI NI 2/5 (40 %) NI NI
Annexin A5 P08758 NI NI 2/5 (40 %) NI NI
ATP bifunctional dihydroxyacetone kinase Q3LXA3 NI NI NI I 5/13 (38 %)
ATP synthase sub unit α P25705 NI NI 3/5 (60 %) NI NI
ATP synthase sub unit β P06576 NI NI I 2/5 (40 %) NI
Carbonic anhydrase 1 P00915 NI NI I NI 4/13 (31 %)
Catalase P04040 NI NI NI 2/5 (40 %) NI
∆(3,5)-∆(2,4)-dienoyl-CoA isomerase Q13011 NI NI I I 4/13 (31 %)
∆-1-pyrroline-5-carboxylate dehydrogenase P30038 NI NI NI NI 4/13 (31 %)
Dihydrolipoyl dehydrogenase P09622 6/13 (46 %) NI I I NI
Electron transfer flavoprotein α P13804 NI NI NI NI 5/13 (38 %)
Epoxyde hydrolase P07099 NI NI NI 2/5
(40 %)
NI
Estradiol 17-β-dehydrogenase 8 Q92506 NI NI NI NI 5/13 (38 %)
Fructose-1.6-biphosphatase 1 P09467 NI NI NI I 5/13 (38 %)
Fructose biphosphate aldolase A P04075 NI 5/13 (38 %) NI NI NI
Fructose biphosphate aldolase B P05062 NI NI NI 4/5 (80 %) 5/13 (38 %)
Glutathione S-transferase P09211 NI 4/13 (31 %) NI NI NI
Glyceraldehyde-3-phosphate dehydrogenase E7EUT4 NI NI I I 7/13 (54 %)
hnRNP C1/C2 G3V4C1 4/13 (31 %) NI NI NI NI
hnRNP K P61978 4/13 (31 %) NI NI NI NI
hnRNP L P14866 7/13 (54 %) NI NI NI NI
HSP1 β1 P04792 NI 7/13 (54 %) I NI NI
HSP 60 P10809 4/13 (31 %) NI NI 3/5 (60 %) NI
Lamin B2 Q03252 NI 5/13 (38 %) NI NI NI
Liver arginase (arginase 1) P05089 NI NI NI 2/5 (40 %) 7/13 (54 %)
Liver carboxyl-esterase 1 E9PAU8 NI NI NI 2/5 (40 %) NI
Prelamine A/C P02545
P02545-2
9/13 (69 %) NI I 3/5 (60 %) 4/13 (31 %)
Proteasome su α2 P25787
G3V295
NI NI 2/5 (40 %) NI NI
Protein phosphatase 1 Q15435 4/13 (31 %) NI NI NI NI
Retinal dehydrogenase 1 P00352 NI 4/13 (31 %) I 2/5 (40 %) NI
Serine hydroxymethyltransferase P34896 NI 5/13 (38 %) NI NI NI
Serotransferrin P02787 NI NI 5/5 (100 %) I NI
Serum albumin P02768 NI NI 2/5 (40 %) 3/5 (60 %) NI
S-methyl-5′ thioadenosine phosphorylase Q13126 NI NI NI NI 5/13 (38 %)
Vimentin P08670 13/13 (100 %) 4/13 (31 %) I NI NI
  1. NI not identified, I recognized by less than 31 % of CC sera. Access numbers are from the Swiss-Prot database