Fig. 9

β-Elemene regulation of stemness-, differentiation- and EMT-related effectors in vivo. a Western blot assays were performed on the aforementioned glioblastoma xenografts in the β-elemene- and NaCl-treated groups. Expression levels of CD133, ABCG2, N-cadherin and β-catenin were significantly downregulated and expression levels of E-cadherin, GFAP, Notch1 and SHH were upregulated by β-elemene. Interestingly, the expression level of vimentin in the β-elemene-treated group was significantly lower than that in the NaCl-treated group; this result was opposite that for the in vitro procedure. b The results are representative of three independent experiments, and the values are presented as the mean ± SD (*p < 0.05, **p < 0.01)