Fig. 1

Criteria for study inclusion. BRCA1 and BRCA2 mutation carriers who were seen in the High Risk Screening Clinic before 2013 and were enlisted in the database for research were included for review. Patients who did not have pathology available, who were treated prior to 1992 (the year our electronic health record was introduced), or who treated at an outside hospital were excluded from the study. Patients who had tumor specimens without adequate tissue for staining were excluded from the study