Fig. 6

Histology of the Ccl2 ^−/− /Cx3cr1 ^−/− /rd8 mouse retina. Representative histological micrographs: fewer lesions in anti-LRP6 treated eyes, as shown by the reduced loss of photoreceptors and more organized retinal structure. Black arrows indicate degenerative photoreceptors in the OPL (top right panel). Red arrows show degeneration and atrophy of ONL and loss of IS/OS in mIgG-injected group (bottom right panel). Some Crb1-associated lesions in the OPL are also seen (asterisk, top left panel) (H&E, original magnification, ×200). GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, IS/OS inner segments/outer segments of photoreceptors