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Table 2 Patient characteristics and response to trastuzumab

From: Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines

 

NEO setting n (%)

MTS setting n (%)

Number of patients

15 (100)

10 (100)

Median age, years (range)

44.1 (29–81)

57.4 (40–91)

 ≤50

8 (53.3)

4 (40.0)

 >50

7 (46.7)

6 (60.0)

Menopausal status

 Pre

8 (53.3)

4 (40.0)

 Post

7 (46.7)

6 (60.0)

Hormonal status

 Either ER+ or PgR+

8 (53.3)

6 (60.0)

 ER−/PgR−

7 (46.7)

4 (40.0)

Number of metastatic sites

 1

5 (50.0)

 ≥2

5 (50.0)

Metastatic sites

 Non visceral

3 (30.0)

 Visceral*

7 (70.0)

Response to trastuzumab

 Complete response

12 (80.0)

3 (30.0)

 Partial response

3 (20.0)

4 (40.0)

 Stable disease

3 (30.0)

  1. NEO neoadjuvant, MTS metastatic, ER estrogen receptor, PGR progesterone receptor (the cut-off value for ER and PGR positivity was ≥1 % of tumor cells with nuclear staining)
  2. * Visceral with or without non visceral metastatic sites