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Table 2 Group differences of circulating lipid and glucose markers

From: Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals

Group

CD

HFD

HFD-DA

HFD-DB

Overall p value

Study duration

22 weeks (n = 6)

43 weeks (n = 6)

22 weeks (n = 6)

43 weeks (n = 5)

43 weeks (n = 6)

43 weeks (n = 5)

 

GLUa (mmol/L)

5.6A (5.3–5.9)

3.9A (3.6–4.1)

6.2A (4.9–6.4)

4.0A (3.9–4.1)

14.4B (9.4–15.2)

8.0C (6.1–8.3)

<0.0001

FRAb (µmol/L)

257A (251–269)

226A (210–237)

251A (229–266)

242A (234–252)

410B (298–444)

340C (322–387)

0.0004

K a,cG (min−1)

4.5AB (3.2–5.1)

5.2A (4.9–6.3)

2.8AB (2.4–3.2)

3.4AB (2.4–5.3)

1.2C (0.4–1.8)

1.4BC (1.1–1.5)

<0.0001

AUC cinsulin (pM min)

4299A (3173–7746)

6943A (6356–7399)

5194A (3676–6236)

11,506B (10,503–12,714)

1992A (1669–4937)

4244A (3368–6747)

0.0003

TG (mmol/L)

0.43A (0.35–0.50)

0.34A (0.29–0.54)

1.09B (1.03–1.36)

1.26B (0.75–2.13)

1.42B (1.26–2.65)

0.92C (0.9–1.45)

0.008

TCa (mmol/L)

1.77A (1.46–2.05)

1.85A (1.53–2.44)

21.70B (19.93–26.76)

16.95B (11.64–25.87)

19.53B (16.59–22.56)

18.87B (17.64–19.18)

<0.0001

VLDLb (mmol/L)

0.07A (0.04–0.10)

0.14A (0.05–0.69)

13.66B (9.49–14.62)

12.50B (7.60–22.32)

12.30B (10.35–14.19)

10.25B (9.58–11.58)

<0.0001

LDLa (mmol/L)

0.72A (0.51–0.85)

0.67A (0.64–1.31)

6.72B (5.12–10.68)

6.22B (4.05–6.57)

5.42B (4.16–6.33)

6.21B (6.01–6.43)

<0.0001

HDLa (mmol/L)

1.00A (0.89–1.11)

0.82A (0.23–1.06)

2.96B (2.60–3.41)

1.26B (1.17–1.38)

1.16B (0.97–1.56)

2.05B (1.45–2.19)

<0.0001

  1. Median and interquartile range (25th–75th)
  2. Values sharing the same superscript letter are not statistically different. A p value <0.05 is considered significant
  3. CD control animals, HFD high-fat/high-cholesterol fed animals, HFD-D A and B high-fat/high-cholesterol fed diabetic animals group A and B, respectively, GLU glucose, FRA fructosamine, K G intravenous glucose tolerance index, AUC Insulin area under the curve of insulin, TG triglycerides, TC total cholesterol, VLDL very-low density lipoprotein, LDL low-density lipoprotein, HDL high-density lipoprotein
  4. aLog-transformed data
  5. bNon-parametric data evaluated in Kruskal–Wallis test
  6. cN = 3 (HFD-D) were excluded due to catheter failure for the intravenous glucose tolerance test (IVGTT)