Fig. 4

Differentiation of radiation necrosis and glioma using APT MRI. MRI of radiation treated animals is performed after 178 days of 40 GY radiation treatment. Radiation necrosis (black arrow) area as revealed by Gd enhancement shows hypointense to isointense on APT weighted image compared to contralateral brain tissue. While both SF188/V + (pink arrow) and 9L (red arrow) tumors show hyperintensity both on the Gd enhanced and APT-weighted images, which correspond to high cellularity. Reproduced with permission from the Nature Publishing Group and Zhou et al. [89]