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Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting
Journal of Translational Medicine volume 13, Article number: 300 (2015)
- The original article was published in Journal of Translational Medicine 2015 13:254
Erratum to: J Transl Med (2015) 13:254 DOI 10.1186/s12967-015-0602-1
The original version of this article unfortunately contained a typographical mistake. In the title of the article, as well as in the body and backmatter of the article, the word ‘phosphate’ was used where ‘phosphatase’ should have been used. Please find below the instances where ‘phosphatase’ should replace ‘phosphate’ in the original article.
Title
A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting
Abstract
Placental like alkaline phosphatase (PLAP), an oncofetal antigen, is highly expressed in germ cell, cervical, ovarian and several other tumour types but minimally in normal tissues. The expression of a PLAP promoter based transcriptional unit following antigen mediated cell specific delivery is a possible approach for tumour targeting.
Keywords
Placental like alkaline phosphatase
Germ cell alkaline phosphatase (GCAP)
Introduction
We reasoned that combining an antibody based targeting modality with a construct based on antigen’s own promoter would provide a novel way for increasing tumour specificity and efficacy. Our laboratory has been working on distinct but immunologically identical oncofetal isozymes of alkaline phosphatases (APs); the placental alkaline phosphatase (PAP) and placental like alkaline phosphatase (PLAP).
Discussion
Germ cell alkaline phosphatase
Abbreviations
AP: alkaline phosphatase; GCAP: germ cell alkaline phosphatase; PAP: placental alkaline phosphatase; PLAP: placental like alkaline phosphatase
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Additional information
The online version of the original article can be found under doi:10.1186/s12967-015-0602-1.
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Open access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Khan, I., Zakaria, M.K., Kumar, M. et al. Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting. J Transl Med 13, 300 (2015). https://doi.org/10.1186/s12967-015-0643-5
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