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Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting

Journal of Translational Medicine volume 13, Article number: 300 (2015) Cite this article

The Original Article was published on 05 August 2015

Erratum to: J Transl Med (2015) 13:254 DOI 10.1186/s12967-015-0602-1

The original version of this article unfortunately contained a typographical mistake. In the title of the article, as well as in the body and backmatter of the article, the word ‘phosphate’ was used where ‘phosphatase’ should have been used. Please find below the instances where ‘phosphatase’ should replace ‘phosphate’ in the original article.

Title

A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting

Abstract

Placental like alkaline phosphatase (PLAP), an oncofetal antigen, is highly expressed in germ cell, cervical, ovarian and several other tumour types but minimally in normal tissues. The expression of a PLAP promoter based transcriptional unit following antigen mediated cell specific delivery is a possible approach for tumour targeting.

Keywords

Placental like alkaline phosphatase

Germ cell alkaline phosphatase (GCAP)

Introduction

We reasoned that combining an antibody based targeting modality with a construct based on antigen’s own promoter would provide a novel way for increasing tumour specificity and efficacy. Our laboratory has been working on distinct but immunologically identical oncofetal isozymes of alkaline phosphatases (APs); the placental alkaline phosphatase (PAP) and placental like alkaline phosphatase (PLAP).

Discussion

Germ cell alkaline phosphatase

Abbreviations

AP: alkaline phosphatase; GCAP: germ cell alkaline phosphatase; PAP: placental alkaline phosphatase; PLAP: placental like alkaline phosphatase

Author information

Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India

    Imran Khan, Mohammad Khalid Zakaria, Parthaprasad Chattopadhyay & Subrata Sinha

  2. National Brain Research Centre, Manesar, Gurgaon, Haryana, 122051, India

    Mohammad Khalid Zakaria, Mukesh Kumar & Subrata Sinha

  3. Department of Biochemistry, University of Delhi, South Campus, Benito Juarez Road, New Delhi, 110021, India

    Prashant Mani & Debi P Sarkar

Authors
  1. Imran Khan
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  2. Mohammad Khalid Zakaria
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  3. Mukesh Kumar
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  4. Prashant Mani
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  5. Parthaprasad Chattopadhyay
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  6. Debi P Sarkar
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  7. Subrata Sinha
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Corresponding authors

Correspondence to Parthaprasad Chattopadhyay, Debi P Sarkar or Subrata Sinha.

Additional information

The online version of the original article can be found under doi:10.1186/s12967-015-0602-1.

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Open access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Khan, I., Zakaria, M.K., Kumar, M. et al. Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting. J Transl Med 13, 300 (2015). https://doi.org/10.1186/s12967-015-0643-5

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  • DOI: https://doi.org/10.1186/s12967-015-0643-5

Journal of Translational Medicine

ISSN: 1479-5876

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