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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: In vitro response pattern of monocytes after tmTNF reverse signaling predicts response to anti-TNF therapy in rheumatoid arthritis

Fig. 2

tmTNF crosslinking-induced cytokine decoy receptor levels are associated with a good response to anti-TNF treatment. ac Scatterplots depict the correlation of tmTNF crosslinking induced monocytic secretion of sTNFR1 (a), sIL-1R1 (b) and sIL-1R2 (c) with the decrease in the patients' DAS28 (ΔDAS28) after 4 weeks of anti-TNF therapy. Each dot represents one patient (n = 18). df Box plots depict the concentrations of the tmTNF crosslinking-induced cytokine decoy receptors sTNFR1 (d), sIL-1R1 (e) and sIL-1R2 (f) in patients with a good response according to the EULAR response criteria (responder, light grey bars, n = 4) compared to patients achieving only a moderate or no response (non-responder, dark grey bars, n = 14). Levels of significance as indicated.

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