Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells

Table 4 Published cancer-associated functions of enriched pathways

Term_ID	miRNAs	Term_name	Relevance to cancer
hsa05200	hsa-miR-215,hsa-miR-338-5p, hsa-miR-378,hsa-miR-760	Pathways in cancer
hsa04060	hsa-miR-338-5p,hsa-miR-378, hsa-miR-450b-5p,hsa-miR-760	Cytokine-cytokine receptor interaction	Cytokines can control invasion and metastasis, and also function to inhibit tumor progression [40]
hsa04810	hsa-miR-338-5p,hsa-miR-378, hsa-miR-450b-5p	Regulation of actin cytoskeleton	Several studies revealed that molecules that link migratory signals to the actin cytoskeleton are upregulated in invasive and metastatic cancer cells [41]
hsa04510	hsa-miR-338-5p, hsa-miR-378	Focal adhesion	Focal adhesion kinase, which plays an important role in tumor progression and metastasis, is overexpressed and activated in a variety of human cancers [42, 43]
hsa04010	hsa-miR-450b-5p	MAPK signaling pathway	The MAPK pathway plays an important role in HCC in that its activation is reportedly involved in HCC growth and survival [35]
hsa04360	hsa-miR-760	Axon guidance	The ligand/receptor pairs of axon guidance regulate tumor angiogenesis [44]
hsa04920	hsa-miR-338-5p	Adipocytokine signaling pathway	Adipocytokine signaling pathway has been demonstrated participate in breast cancer progression [45]
hsa05210	hsa-miR-378	Colorectal cancer
hsa00900	hsa-miR-181c, hsa-miR-29c	Terpenoid backbone biosynthesis
hsa00072	hsa-miR-29c	Synthesis and degradation of ketone bodies

We searched PubMed for published papers to explain the relevance of significantly enriched pathways to cancer. The published cancer-associated-functions of these pathways are listed in this table.

ISSN: 1479-5876