Table 3 Significantly enriched KEGG pathways (p-value <0.05)
From: Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells
miRNA | Term_ID | Term_name | Gene_count | Genes | P-value |
|---|---|---|---|---|---|
hsa-miR-29c | hsa00900 | Terpenoid backbone biosynthesis | 3 | HMGCR, HMGCS1, HMGCS2 | 0.00023 |
hsa-miR-29c | hsa00072 | Synthesis and degradation of ketone bodies | 2 | HMGCS1, HMGCS2 | 0.014 |
hsa-miR-181c | hsa00900 | Terpenoid backbone biosynthesis | 2 | HMGCR, HMGCS1 | 0.012 |
hsa-miR-338-5p | hsa05200 | Pathways in cancer | 10 | RARB, FZD4, ITGA2, IL8, FGF12, DAPK1, EGLN3, PDGFRA, LAMC2, FGF11 | 0.0036 |
hsa-miR-338-5p | hsa04510 | Focal adhesion | 7 | CAV1, CAV2, ITGA2, LAMC2, MYLK3, PDGFRA, VAV3 | 0.012 |
hsa-miR-338-5p | hsa04810 | Regulation of actin cytoskeleton | 7 | VAV3, MYLK3, PDGFRA, ITGA2, FGF11, TIAM2, FGF12 | 0.016 |
hsa-miR-338-5p | hsa04920 | Adipocytokine signaling pathway | 4 | JAK2, ACSL4, PPARGC1A, PRKAB2 | 0.026 |
hsa-miR-338-5p | hsa04060 | Cytokine-cytokine receptor interaction | 7 | CXCL12, GHR, INHBB, IL8, PDGFRA, PRLR, TNFSF4 | 0.038 |
hsa-miR-378 | hsa04510 | Focal adhesion | 5 | COL6A2, ITGA2, MYLK3, PDGFRA, VAV3 | 0.0058 |
hsa-miR-378 | hsa04810 | Regulation of actin cytoskeleton | 5 | VAV3, MYLK3, PDGFRA, ITGA2, FGF12 | 0.0073 |
hsa-miR-378 | hsa04060 | Cytokine-cytokine receptor interaction | 5 | CXCL12, EPO, INHBB, PDGFRA, TGFB2 | 0.014 |
hsa-miR-378 | hsa05200 | Pathways in cancer | 5 | FGF12, FZD4, ITGA2, PDGFRA, TGFB2 | 0.03 |
hsa-miR-378 | hsa05210 | Colorectal cancer | 3 | FZD4, PDGFRA, TGFB2 | 0.038 |
hsa-miR-760 | hsa04060 | Cytokine-cytokine receptor interaction | 6 | CXCL12, EPO, INHBB, PDGFRA, TGFB2, TNFSF4 | 0.011 |
hsa-miR-760 | hsa05200 | Pathways in cancer | 6 | EGLN3, FGF11, FZD4, PDGFRA, TGFB2, RALB | 0.027 |
hsa-miR-760 | hsa04360 | Axon guidance | 4 | CXCL12, EFNA1, NTN4, SEMA7A | 0.03 |
hsa-miR-215 | hsa05200 | Pathways in cancer | 6 | FGF11, FGF12, FZD4, ITGA2, LAMC2, RALB | 0.014 |
hsa-miR-450b-5p | hsa04060 | Cytokine-cytokine receptor interaction | 7 | IL1R1, EPO, CXCL12, TNFSF4, TGFB2, PDGFRA, GHR | 0.029 |
hsa-miR-450b-5p | hsa04010 | MAPK signaling pathway | 7 | IL1R1, DUSP10, TGFB2, PDGFRA, CHP2, MAP3K8, FGF12 | 0.032 |
hsa-miR-450b-5p | hsa04810 | Regulation of actin cytoskeleton | 6 | TIAM2, FGF12, IGF2, ITGA2, PDGFRA, VAV3 | 0.043 |