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Table 2 Semi-quantitative assessment of the regenerated epithelial layer features, inflammatory infiltrate extent, collagen deposition and PCNA-positive nuclei in differently treated wounds at 11 and 21 days

From: Mesenchymal stromal cells for cutaneous wound healing in a rabbit model: pre-clinical study applicable in the pediatric surgical setting

   11 days 21 days p values vs ctrl
Autologous ASCs (n = 14) Epithelial regeneration 3 (2–3) 3 (3–3) p < 0.001
Inflammatory infiltrate 2 (1–2) 1 (1–2) p < 0.001
Collagen deposition 2 (2–3) 3 (2–3) p < 0.001
PCNA-positive nuclei
 Epidermis 3 (1–3) 3 (2–3) p < 0.001
 Dermis 2 (1–3) 2 (2–3)
Allogeneic ASCs (n = 9) Epithelial regeneration 2 (2–2) 1 (1–1) p < 0.001
Inflammatory infiltrate 2 (2–3) 2 (2–3) p = 0.039
Collagen deposition 2 (2–2) 2 (2–2) p < 0.001
PCNA-positive nuclei
 Epidermis 2 (1–3) 2 (1–2) p < 0.01
 Dermis 2 (2–3) 2(2–3)
BM-MSCs (n = 4) Epithelial regeneration 1 (1–2) 1 (1–1) p < 0.001
Inflammatory infiltrate 3 (2–3) 3 (3–3) p = 0.99
Collagen deposition 1 (0–2) 1 (1–1) p = 0.43
PCNA-positive nuclei
 Epidermis 1 (1–2) 2 (2–2) p < 0.01
 Dermis 2 (2–3) 2 (2–2)
Control wounds (n = 27) Epithelial regeneration 0 (0–1) 1 (0–1)  
Inflammatory infiltrate 3 (3–3) 3 (2–3)  
Collagen deposition 0 (0–1) 1 (1–2)
PCNA-positive nuclei
 Epidermis 0 (0–1) 3 (2–3)
 Dermis 0 (0–1) 3 (3–3)
  1. Since no time effect was observed, only the p values (obtained in the multivariable ordinal logistic regression models i.e. corrected for time) relative to group comparisons are reported. Results are reported as the median and range score (Table 1).
  2. ASCs  adipose derived stem cells, BM-MSCs bone marrow derived stem cells.
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Journal of Translational Medicine

ISSN: 1479-5876

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