| |
11 days
|
21 days
|
p values vs ctrl
|
---|
Autologous ASCs (n = 14)
|
Epithelial regeneration
|
3 (2–3)
|
3 (3–3)
|
p < 0.001
|
Inflammatory infiltrate
|
2 (1–2)
|
1 (1–2)
|
p < 0.001
|
Collagen deposition
|
2 (2–3)
|
3 (2–3)
|
p < 0.001
|
PCNA-positive nuclei
|
Epidermis
|
3 (1–3)
|
3 (2–3)
|
p < 0.001
|
Dermis
|
2 (1–3)
|
2 (2–3)
|
Allogeneic ASCs (n = 9)
|
Epithelial regeneration
|
2 (2–2)
|
1 (1–1)
|
p < 0.001
|
Inflammatory infiltrate
|
2 (2–3)
|
2 (2–3)
|
p = 0.039
|
Collagen deposition
|
2 (2–2)
|
2 (2–2)
|
p < 0.001
|
PCNA-positive nuclei
|
Epidermis
|
2 (1–3)
|
2 (1–2)
|
p < 0.01
|
Dermis
|
2 (2–3)
|
2(2–3)
|
BM-MSCs (n = 4)
|
Epithelial regeneration
|
1 (1–2)
|
1 (1–1)
|
p < 0.001
|
Inflammatory infiltrate
|
3 (2–3)
|
3 (3–3)
|
p = 0.99
|
Collagen deposition
|
1 (0–2)
|
1 (1–1)
|
p = 0.43
|
PCNA-positive nuclei
|
Epidermis
|
1 (1–2)
|
2 (2–2)
|
p < 0.01
|
Dermis
|
2 (2–3)
|
2 (2–2)
|
Control wounds (n = 27)
|
Epithelial regeneration
|
0 (0–1)
|
1 (0–1)
| |
Inflammatory infiltrate
|
3 (3–3)
|
3 (2–3)
| |
Collagen deposition
|
0 (0–1)
|
1 (1–2)
|
PCNA-positive nuclei
|
Epidermis
|
0 (0–1)
|
3 (2–3)
|
Dermis
|
0 (0–1)
|
3 (3–3)
|
- Since no time effect was observed, only the p values (obtained in the multivariable ordinal logistic regression models i.e. corrected for time) relative to group comparisons are reported. Results are reported as the median and range score (Table 1).
-
ASCs adipose derived stem cells, BM-MSCs bone marrow derived stem cells.