Figure 2
Scatter plot matrix showing the relationship amongst genes found to be differentially expressed in ONJ subjects. Top panel N-BP treatment naive controls show large inter-individual variance in the leukocyte expression levels of the immune and wound healing genes, which show a high degree of correlation. Bottom panel intravenous N-BP exposure (green) perceptibly reduced within-group variance in expression levels which were shifted to being highly clustered; ONJ cases (purple), however, clearly failed to respond similarly to N-BP exposure and the immune and wound healing gene expression levels remained markedly reduced. Note- data represent the actual normalized Ct values, thus higher values moving left to right within the matrix correspond to lower gene expression. Statistical differences between groups are reported in Table 2.