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Table 3 Univariable and multivariable Cox regression analysis of the lncRNA signature and overall survival of NSCLC patients in the training and two independent cohorts

From: A potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer

Variables

Univariable analysis

Multivariable analysis

HR

95% CI of HR

P value

HR

95% CI of HR

P value

GSE37745 training set, n = 196

 Eight-lncRNA risk score

  Low risk/high risk

2.641

1.887–3.697

<0.001

2.761

1.934–3.942

<0.001

 Age

  ≤65/>65

1.355 

0.977–1.878

0.069

1.427 

1.024–1.986

0.035

 Gender

  Female/male

1.096

0.789–1.523

0.585

0.913 

0.640–1.303

0.616

 Stage

  I

1 (reference)

  

1 (reference)

  

  II

1.220

0.793–1.875

0.366

1.169

0.758–1.802

0.479

  III

1.864

1.187–2.928

0.007

1.656

1.052–2.608

0.029

  IV

1.313

0.415–4.152

0.643

1.566

0.488–5.022

0.451 

 Subtype

  Adenocarcinoma

1 (reference)

  

1 (reference)

  

  Large cell carcinoma

0.891

0.520–1.528

0.675

0.782

0.449–1.360

0.383

  Squamous cell carcinoma

1.257

0.883–1.791

0.205

0.920

0.623–1.359

0.676

GSE31210 testing set, n = 226

 Eight-lncRNA risk score

  Low risk/High risk

3.067

1.471–6.395

0.003

2.643

1.263–5.528

0.010

 Age

  ≤65/>65

2.584

1.313–5.083

0.006

3.685

1.800–7.544

<0.001

 Gender

  Female/male

1.519

0.780–2.955

0.219

1.143

0.402–3.246

0.802

 Smoking status

  No/Yes

1.637

0.837–3.201

0.15

1.388

0.482–3.996

0.544

 Stage

  I/II

4.232

2.175–8.236

<0.001

4.363

2.161–8.811

<0.001

GSE50081 testing set, n = 181

 Eight-lncRNA risk score

  Low risk/high risk

1.795

1.127–2.859

0.014

1.752

1.014–3.026

0.044

 Age

  ≤65/>65

1.559

0.932–2.608

0.090

1.316

0.752–2.303

0.336

 Gender

  Female/male

1.934

1.190–3.143

0.008

1.743

1.011–3.005

0.046

 Smoking status

  No/Yes

1.387

0.659–2.916

0.389

1.054

0.476–2.333

0.897

 Stage

  I/II

1.689

1.049–2.718

0.031

2.359

1.379–4.034

0.002

 Subtype

  Adenocarcinoma

1 (reference)

  

1 (reference)

  

  Large cell carcinoma

1.326

0.479–3.671

0.587

1.094

0.376–3.184

0.870

  Squamous cell carcinoma

0.791

0.456–1.371

0.403

0.479

0.241–0.952

0.036

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Journal of Translational Medicine

ISSN: 1479-5876

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