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Table 3 Univariable and multivariable Cox regression analysis of the lncRNA signature and overall survival of NSCLC patients in the training and two independent cohorts

From: A potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer

Variables Univariable analysis Multivariable analysis
HR 95% CI of HR P value HR 95% CI of HR P value
GSE37745 training set, n = 196
 Eight-lncRNA risk score
  Low risk/high risk 2.641 1.887–3.697 <0.001 2.761 1.934–3.942 <0.001
 Age
  ≤65/>65 1.355  0.977–1.878 0.069 1.427  1.024–1.986 0.035
 Gender
  Female/male 1.096 0.789–1.523 0.585 0.913  0.640–1.303 0.616
 Stage
  I 1 (reference)    1 (reference)   
  II 1.220 0.793–1.875 0.366 1.169 0.758–1.802 0.479
  III 1.864 1.187–2.928 0.007 1.656 1.052–2.608 0.029
  IV 1.313 0.415–4.152 0.643 1.566 0.488–5.022 0.451 
 Subtype
  Adenocarcinoma 1 (reference)    1 (reference)   
  Large cell carcinoma 0.891 0.520–1.528 0.675 0.782 0.449–1.360 0.383
  Squamous cell carcinoma 1.257 0.883–1.791 0.205 0.920 0.623–1.359 0.676
GSE31210 testing set, n = 226
 Eight-lncRNA risk score
  Low risk/High risk 3.067 1.471–6.395 0.003 2.643 1.263–5.528 0.010
 Age
  ≤65/>65 2.584 1.313–5.083 0.006 3.685 1.800–7.544 <0.001
 Gender
  Female/male 1.519 0.780–2.955 0.219 1.143 0.402–3.246 0.802
 Smoking status
  No/Yes 1.637 0.837–3.201 0.15 1.388 0.482–3.996 0.544
 Stage
  I/II 4.232 2.175–8.236 <0.001 4.363 2.161–8.811 <0.001
GSE50081 testing set, n = 181
 Eight-lncRNA risk score
  Low risk/high risk 1.795 1.127–2.859 0.014 1.752 1.014–3.026 0.044
 Age
  ≤65/>65 1.559 0.932–2.608 0.090 1.316 0.752–2.303 0.336
 Gender
  Female/male 1.934 1.190–3.143 0.008 1.743 1.011–3.005 0.046
 Smoking status
  No/Yes 1.387 0.659–2.916 0.389 1.054 0.476–2.333 0.897
 Stage
  I/II 1.689 1.049–2.718 0.031 2.359 1.379–4.034 0.002
 Subtype
  Adenocarcinoma 1 (reference)    1 (reference)   
  Large cell carcinoma 1.326 0.479–3.671 0.587 1.094 0.376–3.184 0.870
  Squamous cell carcinoma 0.791 0.456–1.371 0.403 0.479 0.241–0.952 0.036