Group | Parameter | Baseline | ROSC 0Â min | ROSC 30Â min | ROSC 1Â h | ROSC 2Â h | ROSC 4Â h | ROSC 6Â h | Number of shocks to initial ROSC | Total adrenaline dose (mg) | 6Â h survival | 24Â h survival |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Saline group | HR | 101.38 ± 8.30 | 132.2 ± 11.3** | 129.4 ± 10.4** | 120.3 ± 8.9** | 118.9 ± 9.3** | 113.5 ± 17.4* | 101.4 ± 10.4 | 4.9 ± 1.2 | 1.9 ± 0.7 | 5 (8) | 3 (8) |
CO | 2.99 ± 0.20 | 0.91 ± 0.07** | 0.88 ± 0.06** | 0.89 ± 0.06** | 0.91 ± 0.05** | 1.04 ± 0.05** | 1.15 ± 0.04** | |||||
MAP | 91.88 ± 3.22 | 125.2 ± 7.3** | 122.5 ± 6.4** | 115.4 ± 6.1** | 109.8 ± 5.7** | 107.6 ± 5.1** | 101.5 ± 4.8* | |||||
CPP | 44.2 ± 4.12 | 22.3 ± 2.5** | 23.4 ± 2.6** | 25.6 ± 2.7** | 29.7 ± 3.6** | 32.5 ± 3.8* | 33.8 ± 3.7* | |||||
MPAP | 24.1 ± 2.2 | 49.7 ± 6.3** | 47.3 ± 5.7** | 43.8 ± 4.7** | 39.7 ± 4.2** | 35.8 ± 3.7* | 35.1 ± 3.1* | |||||
LVEF % | 41.3 ± 7.4 | 24.3 ± 1.2** | 26.4 ± 2.3** | 29.4 ± 2.7** | 32.3 ± 3.5* | 33.5 ± 4.3* | 34.6 ± 3.3* | |||||
Sildenafil group | HR | 102.18 ± 7.30 | 123.2 ± 9.3**Δ | 118.4 ± 8.4**Δ | 115.3 ± 7.9** | 110.9 ± 6.3*Δ | 107.5 ± 5.4Δ | 105.4 ± 4.4 | 2.1 ± 0.6Δ | 0.8 ± 0.3Δ | 7 (8) | 7 (8)Δ |
CO | 2.99 ± 0.20 | 0.99 ± 0.06** | 1.12 ± 0.03** | 1.23 ± 0.04**Δ | 1.34 ± 0.08**Δ | 1.42 ± 0.07**Δ | 1.36 ± 0.08** | |||||
MAP | 89.88 ± 3.22 | 117.2 ± 7.1**Δ | 115.5 ± 5.9**Δ | 111.8 ± 5.6** | 103.6 ± 4.7**Δ | 99.8 ± 4.3*Δ | 94.5 ± 3.4 | |||||
CPP | 43.1 ± 3.34 | 27.6 ± 2.8**Δ | 28.2 ± 2.9**Δ | 32.4 ± 3.1** | 35.4 ± 3.6*Δ | 36.5 ± 3.9Δ | 39.4 ± 4.3Δ | |||||
MPAP | 24.6 ± 2.7 | 40.3 ± 5.6**Δ | 38.4 ± 4.1**Δ | 37.8 ± 4.1**Δ | 33.6 ± 3.5*Δ | 29.8 ± 3.1Δ | 28.7 ± 2.2Δ | |||||
LVEF % | 43.1 ± 6.9 | 27.3 ± 1.3** | 30.7 ± 2.8** | 32.3 ± 3.1* | 38.7 ± 3.9*Δ | 39.5 ± 4.1Δ | 40.9 ± 4.1Δ |