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Figure 2 | Journal of Translational Medicine

Figure 2

From: Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differential restoration of blood profiles by NAC and surgery

Figure 2

Blood NK cell cytotoxicity (apoptosis and necrosis of K562 cells—see “Patients and methods” for further details) elicited by BMCs for Groups I and II and Groups III and IV women with LLABCs undergoing NAC. There was no significant difference observed between baseline levels (prior to NAC) (Groups I and II: 38.3 ± 8.40%; Groups III and IV: 22.4 ± 7.6%), following eight cycles of chemotherapy (Groups I and II: 45.2 ± 4.40%; Groups III and IV: 24.4 ± 1.50%) and after surgery (Groups I and II: 35 ± 3.00%; Groups III and IV: 22.4 ± 2.90%). Spontaneous activity in the assays was ≤4%. SPSS (version 19.0) used for data analysis and calculation of independent sample t tests for statistical significance.

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Journal of Translational Medicine

ISSN: 1479-5876

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