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Table 2 Mean (±SD) pharmacokinetic parameters of propofol following fospropofol administration in rats

From: Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers

Route

Dose (mg/kg)

Cmax (µg/mL)

AUC(0−t) (µg h/mL)

AUC0−∞(µg h/mL)

T1/2 (h)

Fa (%)

IV

5

0.29 (±0.04)

0.12 (±0.02)

0.14 (±0.03)

ND

ND

PO

20

0.04 (±0.001)

0.06 (±0.04)

0.13 (±0.12)

4.66 (±4.13)

22.7

PO

100

0.53 (±0.08)

1.21 (±0.2)

1.96 (±0.6)

4.13 (±1.12)

70.5

ID

30

1.27 (±0.87)

0.353 (±0.14)

0.398 (±0.14)

2.85 (±0.87)

47.3

ID

100

5.84 (±2.29)

3.57 (±0.57)

3.95 (±0.48)

2.32 (±0.73)

141

  1. aRatio of mean of AUC(0−∞) to reference treatment of 5 mg/kg IV fospropofol.
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Journal of Translational Medicine

ISSN: 1479-5876

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