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Table 2 Mean (±SD) pharmacokinetic parameters of propofol following fospropofol administration in rats

From: Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers

Route Dose (mg/kg) Cmax (µg/mL) AUC(0−t) (µg h/mL) AUC0−∞(µg h/mL) T1/2 (h) Fa (%)
IV 5 0.29 (±0.04) 0.12 (±0.02) 0.14 (±0.03) ND ND
PO 20 0.04 (±0.001) 0.06 (±0.04) 0.13 (±0.12) 4.66 (±4.13) 22.7
PO 100 0.53 (±0.08) 1.21 (±0.2) 1.96 (±0.6) 4.13 (±1.12) 70.5
ID 30 1.27 (±0.87) 0.353 (±0.14) 0.398 (±0.14) 2.85 (±0.87) 47.3
ID 100 5.84 (±2.29) 3.57 (±0.57) 3.95 (±0.48) 2.32 (±0.73) 141
  1. aRatio of mean of AUC(0−∞) to reference treatment of 5 mg/kg IV fospropofol.