Figure 2

Sedation induced by fospropofol administered via a IV, b PO and c ID routes. The scoring system was on a 0–4 scale where 0 = alert and completely responsive, 1 = alert but less active and ‘wobbly’, 2 = awake but drowsy with periods of in-activity, 3 = generally sedated/inactive but readily arousable, 4 = unresponsive or unconscious. Sedative activity was assessed by blinded observers in 2–3 rats per treatment group.