Table 4 Network and pathway analysis showing the most likely candidate genes with functional relevance in autoimmunity
From: Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome
Gene | Network algorithm (P value) | Network node | GeneGO ontology process | Processes P value |
|---|---|---|---|---|
LRP1 | Analyse network (3.03e−7) | PKC alpha (phosphorylation of the A2M receptor encoded by LRP1) (Figure 1) | Phagocytosis | 7.596e−8 |
LRP1 | Analyse network (3.03e−7) | PKC-alpha (phosphorylation of the A2M receptor encoded by LRP1) (Figure 1) | Regulation of phospholipase A2 activity | 3.597e−13 |
LRP1 | Analyse network (3.03e−7) | PKC-alpha (phosphorylation of the A2M receptor encoded by LRP1) (Figure 1) | Negative regulation of apoptosis | 6.703e−21 |
LRP1 | Shortest paths (N/A) | LRP1 (transcription regulation) IFN-gamma (Figure 2) | Response to lipopolysaccharide | 7.616e−21 |
MICAL1 | Analyse network (7.32e−10) | PKC-mu MICAL1 (Figure 3) | Negative regulation of apoptotic process | 7.901e−15 |
MICAL1 | Analyse network (7.32e−10) | PKC-mu MICAL1 (Figure 3) | Actin filament depolymerisation | 2.34e−2 |
MICAL1 | Analyse network (7.32e−10) | PKC-mu MICAL1 (Figure 3) | Negative regulation of cysteine type endopeptidase activity | 5.403e−3 |