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Table 1 Verified direct targets of miR-373

From: Diverse functions of miR-373 in cancer

Gene Symbol Description Regulationa References
LATS2 large tumor tuppressor, homolog 2 [7, 10, 12, 21]
CD44 CD44 molecule [8, 11, 21]
CDH1 cadherin 1, type 1, E-cadherin [4, 2931]
CSDC2 cold shock domain containing C2, RNA binding [4]
RAD52 Rad52 DNA Repair and Recombination Protein [9]
RAD23B RAD23 homolog B [9]
MBD2 methyl-CpG binding domain protein 2 [13]
NFIB nuclear factor I/B [17]
RAB22A RAB22A, member RAS oncogene family [16, 24]
PPP6C protein phosphatase 6, catalytic subunit [14]
TXNIP thioredoxin interacting protein [15]
RABEP1 rabaptin, RAB GTPase binding effector protein 1 [15]
RelA v-rel avian reticuloendotheliosis viral oncogene homolog A [22, 27]
TGFBR2 transforming growth factor-beta type II receptor [19, 22]
mTOR Mammalian Target of Rapamycin [18]
SIRT sirtuin (silent mating type information regulation 2 homolog) [18]
DKK1 dickkopf homolog 1 [19]
BTG1 B-cell translocation gene 1, anti-proliferative protein [19]
LEFTY1 left-right determination factor 1 [19]
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 [20]
TP53INP1 tumor protein p53 inducible nuclear protein 1 [21]
IRAK2 interleukin-1 receptor-associated kinase 2 [23]
LAMP1 lysosomal-associated membrane protein 1 [23]
MMP14 matrix metallopeptidase 14 (membrane-inserted) [25]
ER estrogen receptor [26]
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [27]
JAK1 Janus kinase 1 [28]
IRF9 interferon regulatory factor 9 [28]
  1. aExpression regulation of target genes by miR-373: ↓ represents down-regulation, ↑ represents up-regulation