Diverse functions of miR-373 in cancer

Table 1 Verified direct targets of miR-373

Gene Symbol	Description	Regulation^a	References
LATS2	large tumor tuppressor, homolog 2	↓	[7, 10, 12, 21]
CD44	CD44 molecule	↓	[8, 11, 21]
CDH1	cadherin 1, type 1, E-cadherin	↑	[4, 29–31]
CSDC2	cold shock domain containing C2, RNA binding	↑	[4]
RAD52	Rad52 DNA Repair and Recombination Protein	↓	[9]
RAD23B	RAD23 homolog B	↓	[9]
MBD2	methyl-CpG binding domain protein 2	↓	[13]
NFIB	nuclear factor I/B	↓	[17]
RAB22A	RAB22A, member RAS oncogene family	↓	[16, 24]
PPP6C	protein phosphatase 6, catalytic subunit	↓	[14]
TXNIP	thioredoxin interacting protein	↓	[15]
RABEP1	rabaptin, RAB GTPase binding effector protein 1	↓	[15]
RelA	v-rel avian reticuloendotheliosis viral oncogene homolog A	↓	[22, 27]
TGFBR2	transforming growth factor-beta type II receptor	↓	[19, 22]
mTOR	Mammalian Target of Rapamycin	↓	[18]
SIRT	sirtuin (silent mating type information regulation 2 homolog)	↓	[18]
DKK1	dickkopf homolog 1	↓	[19]
BTG1	B-cell translocation gene 1, anti-proliferative protein	↓	[19]
LEFTY1	left-right determination factor 1	↓	[19]
TNFAIP1	tumor necrosis factor, alpha-induced protein 1	↓	[20]
TP53INP1	tumor protein p53 inducible nuclear protein 1	↓	[21]
IRAK2	interleukin-1 receptor-associated kinase 2	↓	[23]
LAMP1	lysosomal-associated membrane protein 1	↓	[23]
MMP14	matrix metallopeptidase 14 (membrane-inserted)	↓	[25]
ER	estrogen receptor	↓	[26]
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	↓	[27]
JAK1	Janus kinase 1	↓	[28]
IRF9	interferon regulatory factor 9	↓	[28]

^aExpression regulation of target genes by miR-373: ↓ represents down-regulation, ↑ represents up-regulation

ISSN: 1479-5876