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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors

Fig. 4

CARhi phenotype does not require high genomic copy number of CAR transgene. a Relative genomic CAR copy number in three sorted CAR–T-cell populations as determined by quantitative PCR relative to the housekeeping gene β-actin. The lowest copy number is set to 1. Values are averages of quadruplicates with error bars indicating ± 1 s.d. b CAR–T-cell populations with varying genomic CAR copy number separate into CARhi/CD25+ and CARlo/CD25 populations within 18 h of antigen simulation

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