18 F-FCH uptake as a percentage of the administered activity normalized to protein content. 18 F-FCH uptake as a percentage of the administered activity normalized to protein content in the Hey (a) and cisplatin-resistant Heycis
(b) cell lines. Cisplatin-resistant Heycis cells demonstrated lower mean 18 F-FCH uptake compared to parental Hey cells (5.42% ± 0.23% vs. 3.79% ± 0.14% of administered activity). At 2.5 μmol/L cisplatin, both tested cerulenin concentrations decreased 18 F-FCH uptake in cisplatin-resistant Heycis cells. For the parental Hey cells, this effect was only detectable at the higher cerulenin concentration. Treatment with cerulenin alone did not affect the cellular uptake of 18 F-FCH in any tested cell line. cis = cisplatin; cer = cerulenin.