Figure 8

¹⁸ F-FCH uptake as a percentage of the administered activity normalized to protein content. ¹⁸ F-FCH uptake as a percentage of the administered activity normalized to protein content in the Hey (a) and cisplatin-resistant Hey_cis (b) cell lines. Cisplatin-resistant Hey_cis cells demonstrated lower mean ¹⁸ F-FCH uptake compared to parental Hey cells (5.42% ± 0.23% vs. 3.79% ± 0.14% of administered activity). At 2.5 μmol/L cisplatin, both tested cerulenin concentrations decreased ¹⁸ F-FCH uptake in cisplatin-resistant Hey_cis cells. For the parental Hey cells, this effect was only detectable at the higher cerulenin concentration. Treatment with cerulenin alone did not affect the cellular uptake of ¹⁸ F-FCH in any tested cell line. cis = cisplatin; cer = cerulenin.