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Table 1 Cytokine and LST results of the women in the four groups with different HPV-status

From: Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years

Cytokine results

Stimulant

Cytokine

Study groups

Mean value I

Mean value II

p value

MRM

IFN-γ

Group 1 vs. Group 2

908.087

309.916

0.026

  

Group 1 vs. Group 3

908.088

275.220

0.003

  

Group 1 vs. Group 4

908.089

404.942

0.043

HPV16 E6-4

IFN-γ

Group 3 vs. Group 4

5.220

56.783

0.034

HPV16 pooled E6

IFN-γ

Group 3 vs. Group 4

11.318

69.173

0.050

LST results

     
 

Stimulant

Study groups

Mean value I

Mean value II

p value

 

MRM

Group 1 vs. Group 2

118.493

214.323

0.005

  

Group 1 vs. Group 3

118.493

51.455

0.023

  

Group 1 vs. Group 4

118.493

44.385

0.021

  

Group 2 vs. Group 3

214.323

51.455

0.0001

  

Group 2 vs. Group 4

214.323

44.385

0.0001

  1. Group 1 (n = 5): HPV16 + and a CIN lesion caused by HPV16; Group 2 (n = 5): HPV16 + and a CIN lesion with another or unknown HPV genotype; Group 3 (n = 14): Oral HPV16+/HPV seropositive and no cervical HPV; Group 4 (n = 8): Oral HPV16+/HPV seronegative and no cervical HPV.