Table 2 Frequent genetic aberrations in osteosarcoma
From: Establishment of a patient-derived orthotopic osteosarcoma mouse model
Gene locus (locus name) | Human tissue OS-RH-2011 | Orthotopic mouse tumor P3 | Subcutaneous mouse tumor P3 | Primary cell cultureP3* |
|---|---|---|---|---|
1p22.3 (BCL10) | Gain / amplification | Gain / amplification | No variation | Gain / amplification |
3q13.31 (LSAMP) | LOH / Del | LOH / Del | No variation | LOH / Del |
3p26.1 (SUMF1) | No variation | No variation | LOH / Del | No variation |
6p21.1 (RUNX2) | Gain / amplification | Gain / amplification | No variation | Gain / amplification |
7q31.33 (POT1) | Gain / amplification | Gain / amplification | No variation | Gain / amplification |
8q24.21 (Myc) | Gain / amplification | Gain / amplification | Gain / amplification | Gain / amplification |
13q14 (RB1) | LOH / Del | LOH / Del | LOH / Del | LOH / Del |
17p13.1 (TP53) | Gain / amplification | Gain / amplification | No variation | Gain / amplification |
17q25.1 (SLC25A19) | Gain / amplification | Gain / amplification | No variation | Gain / amplification |
19q13 (GLTSCR1) | Gain / amplification | Gain / amplification | No variation | Gain / amplification |