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Table 2 Frequent genetic aberrations in osteosarcoma

From: Establishment of a patient-derived orthotopic osteosarcoma mouse model

Gene locus (locus name) Human tissue OS-RH-2011 Orthotopic mouse tumor P3 Subcutaneous mouse tumor P3 Primary cell cultureP3*
1p22.3 (BCL10) Gain / amplification Gain / amplification No variation Gain / amplification
3q13.31 (LSAMP) LOH / Del LOH / Del No variation LOH / Del
3p26.1 (SUMF1) No variation No variation LOH / Del No variation
6p21.1 (RUNX2) Gain / amplification Gain / amplification No variation Gain / amplification
7q31.33 (POT1) Gain / amplification Gain / amplification No variation Gain / amplification
8q24.21 (Myc) Gain / amplification Gain / amplification Gain / amplification Gain / amplification
13q14 (RB1) LOH / Del LOH / Del LOH / Del LOH / Del
17p13.1 (TP53) Gain / amplification Gain / amplification No variation Gain / amplification
17q25.1 (SLC25A19) Gain / amplification Gain / amplification No variation Gain / amplification
19q13 (GLTSCR1) Gain / amplification Gain / amplification No variation Gain / amplification
  1. Loss of heterozygocity (LOH) was defined as log2 ratio per clone > − 0.25, Amplification was defined as log2 ratio per clone > 0.25.