Figure 2

Master Regulators of the IBC signature. A: The network shows the top-three MRs (round white nodes) with their respective inferred targets (red or green round nodes). The figure reports just the differentially expressed genes in each regulon. Red nodes depict up-regulated target genes in IBC, and green nodes represent down-regulated targets. The gene network is deeply interconnected, showing a partial overlapping among the three regulons and also gene interactions among the main hubs (edges between white nodes). B: Venn diagram of the overlapping between DEGs and the three regulons. C: Enrichment of known binding motifs for NFAT5 in its inferred regulon. The occurrence of motif sites is shown as the distance between the TSS of the genes in the regulon and the nearest motif encountered (red line). This was compared with the occurrence of random sites of the same length in the same regulons derived for a random motif. Motifs are taken from Transfac and Human-jolma 2013 databases. D: Same as in C for MGA.