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Archived Comments for: Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer

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  1. On NFAT regulation

    sebastien jauliac, INSERM

    1 May 2015

    This paper is another critical step on the wide role of NFAT factor in breast cancer as we showed for the fist time in 2002 (Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol. 2002;4(7):540–4.)

    I would like to thanks the author for this nice study.

     

    But in the discussion on the regulation of NFAT factors where our study is indicated, there is  a misundertanding about NFAT5 regulation. NFAT1 to NFAT4 are effectively regulated  by DYRK1  and ,when they are deposphorylate by the calcineurin, they translocate to the nucleus to regulate their target genes. 

    For NFAT5, this is not the case, this is the sole member of the NFAT family that is no regulated by the calcineurin and need to dimerize to get activated. Its mechanisms of activation are completely different than the other NFAT members and still largely unknown.

     

    I think it was an important point to do.

     

    But again thanks for your nice study.

    Competing interests

    We work on NFAT and breast cancer. We were the first to identify their expression and function in breast cancer. My point was only to make a correction on the description of NFAT5 regulation that is different from the other NFAT member.

    I find this study really interesting and I don't think I have any competing interests.

  2. RE: On NFAT regulation

    Michele Ceccarelli, Qatar Computing Research Institute

    12 May 2015

    Hi Sebastien,

    thanks for your comment. It is much appreciated that an expert of NFAT signalling finds the paper interesting. I agree 100% with your clarification. The discussion was intended to describe in general what it is known about the NFAT family and not just NFAT5. As you reported in the paper (Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol. 2002;4(7):540–4) NFAT5 lacks  most of the regulatory domain present in NFAT1 to NFAT4 and its  mechanisms are still largely unknown.

     

     

     

    Competing interests

    I am an author of the above paper.

    My comment is in reply of the previous clarification, I complitely agree with the comment stating that the specific mechanisms of activition of NFAT5 should be further explored.

     

     

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