Figure 2

Procollagen processing by ADAMTS2, BMP1 and TACE. A.: Cleavage of the ecto-domain of collagen α1(XVII) by TACE. The sequence of the cleavage site of TACE (box) and the phosphorylated residues (highlighted in red) are shown. The color coding to represent the position of the phosphorylated sites used is red (human) and blue (mouse). Collagen structures are represented as described [61]. B-E.: Cleavage of the N- and C-propeptide of collagen I-III. The sequences of the N- and C-propeptide are shown in the box. Experimentally verified phosphorylated sites (red letters) and known mutations (black bold) leading to diseases are highlighted. Cleavage site of the enzymes are marked. Collagen structures are represented as described [61].