Figure 5

miR-125b plays an important role in anti-tumor effect of GLPS. For down-regulation of miR-125b, miR-125b inhibitor was injected intratumorally before GLPS administration. Twenty-four hours after the miR-125b inhibitor (10 nmol) injection, hepatoma-bearing mice were treated with 50 mg/kg GLPS or same volume of PBS by i.p. injection. (A) Tumor sizes on each mouse were monitored 2 times per week. (B) Tumor weights were measured and the images of tumors from different treatment group were shown. (C) The expression of miR-126b in Tregs from hepatoma-bearing mice were measured. **P < 0.01 indicated significant differences from negative control injection. # P < 0.05 and ## P < 0.01, indicate significant differences from negative control + GLPS.