Figure 5

Potential effect modifiers sex, Age, and BMI have no clear influence on serum inflammatory potential. Sex related differences are negligible in determining the differences between healthy and CAD serum-induced endothelial cell responses (A-C). Similarly, Age does not appear to drive any trends for serum-induced IL-8, ICAM-1, or VCAM-1 mRNA expression (D-F). While BMI is limited in the control population, the lack of consistent trends in controls and CAD across various BMI ranges reduces confidence that this factor has a clear role in drive the serum inflammatory potential (G-I).