The prognostic role of systemic inflammatory markers on HIV-infected patients with non-Hodgkin lymphoma, a multicenter cohort study

Table 3 Univariate and multivariate Cox regression models for each inflammatory prognostic variable

Variables	Category ^$			Univariate model			Multivariate model
Variables	Category ^$	n (%) ^#	n	HR (95% CI)	P value	n	HR (95% CI) ^π	P value
GPS*	0	20 (25.3)	79	Ref		65	Ref
GPS*	1	42 (53.2)		1.82 (0.49-6.69)	NS		1.91 (0.45-7.65)	NS
	2	17 (21.5)		4.39 (1.19-16.2)	0.026		4.78 (1.15-19.77)	0.031
	Available	79 (36.7)
mGPS*	0	24 (30.4)	79	Ref		65	Ref
	1	38 (48.1)		2.01 (0.61-7.00)	NS		2.07 (0.61-7.01)	NS
	2	17 (21.5)		4.46 (1.36-14.6)	0.013		4.35 (1.16-16.36)	0.029
	Available	79 (36.7)
NLR	0	129 (67.2)	192	Ref
	1	32 (16.7)		1.31 (0.74-2.30)	NS
	2	31 (16.1)		1.48 (0.84-2.61)	NS
	Mean (SD)	2.92 (2.79)
	Available	192 (89.3)
PLR	0	97 (48.3)	199	Ref
	1	67 (33.3)		1.16 (0.71-1.90)	NS
	2	37 (18.4)		1.58 (0.88-2.84)	NS
	Mean (SD)	193.7 (135.1)
	Available	199 (92.6)
PI*	0	29 (31.9)	91	Ref		77	Ref
	1	60 (65.9)		3.33 (1.12-9.93)	0.030		3.25 (1.06-9.94)	0.039
	2	2 (2.2)		3.98 (0.86-28.35)	NS		11.3 (1.03-124.9)	0.047
	Available	91 (42.3)
PNI*	0	54 (39.7)	136	Ref		114	Ref
	1	82 (60.3)		2.36 (1.23-4.53)	0.010		2.57 (1.25-5.30)	0.010
	Available	136 (63.3)

Abbreviations: HR Hazard Ratio, 95% CI, 95% Confidence Interval, SD Standard Deviation, GPS Glasgow Prognostic Score, mGPS modified Glasgow Prognostic Score, NLR Neutrophil/Lymphocyte Ratio, PLR Platelet/Lymphocyte Ratio, PI Prognostic Index, PNI Prognostic Nutritional Index, NS Not Statistical Significant (p > 0.05).
^#Colum percentage, *Weighted Cox regression models, ^πModel adjusted for gender, age at diagnosis, intravenous drug user, AIDS defining event, CD4 cell count and HIV-RNA undetectable. ^$For prognostic variables classification see Table 1.

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