Figure 1
From: Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis
Metformin, an FDA approved drug for type-II diabetes as a potential combination therapy for Tuberculosis with existing antibiotics. a) Antibiotic targeting mycolic acid biosynthesis; b) systems-level changes resulting into the reduction of flux carrying capacity of glycolysis and citric acid cycle c) resulting re-routing of metabolic fluxes through de novo NAD biosynthesis pathway and electron transport through NDH-I d) possibility of targeting NDH-I with metformin.