Table 1 AQPs expression in different human tumors
From: Aquaporins as diagnostic and therapeutic targets in cancer: How far we are?
Aquaporins | Tumor type | Correlated function |
|---|---|---|
AQP1 | Brain cancer [13], Breast cancer [35], Colorectal cancer [34], Cervical cancer, Laryngeal cancer, Lung cancer [43], Nasopharyngeal cancer, Ovarian cancer [37] | Tumor grade, prognosis, tumor angiogenesis, tumor necrosis, tumor cell migration, tumor invasion and metastasis. |
AQP3 | Colorectal cancer [34], Cervical cancer, Liver cancer [40], Lung cancer [9], Oesophageal cancer [39], Renal cancer [41], Skin cancer [38], Stomach cancer, Tongue cancer [42] | Tumor grade, prognosis, tumor angiogenesis, tumor invasion, tumor cell migration and tumor energy metabolism. |
AQP4 | Tumor grade, migration, tumor-associated edema, adhesion, invasion and tumor apoptosis. | |
AQP5 | Breast cancer [9], Colorectal cancer [34,45], Cervical cancer, Leukaemia [46], Liver cancer [40], Lung cancer [47], Oesophageal cancer [39], Ovarian cancer [48], Stomach cancer [49], Tongue cancer [42] | Tumor prognosis, tumor proliferation, tumor invasion, tumor cell migration and drug resistance. |
AQP7 | Thyroid cancer [50] | Unknown |
AQP8 | Cervical cancer | Tumor cell migration, tumor invasion, tumor metastasis and anti-apoptosis. |
AQP9 | Tumor grade, drug resistance and energy metabolism. |