Biological insights regarding miR-130a. (A) Heat map of the gene expression signature correlated with miR-130a expression. Columns represent patients and rows represent probes. Patients are ordered from left to right by increasing miR-130a expression. (B) The top 10 gene ontology terms for miR-130a negatively associated genes. (C) Gene set enrichment analysis showed enrichment of genes related to response to oxidative stress among patients with low miR-130a expression. NES, normalized enrichment score. (D) SHG44 transfected with the scrambled control (SHG44-SC) expressed higher Ape1 than cells transfected with miR-130a mimics (SHG44-M) did under oxidative stress. (E) U251 transfected with the scrambled control (U251-SC) expressed lower Ape1 than cells transfected with miR-130a inhibitors (U251-I) did under oxidative stress.