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Table 1 Overview of GSC panel drug screening results

From: ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells

GS ID Histology Age OS MGMT Blot/Methyl PARPi TMZ Enhancement factor TMZ 50 p-value Enhancement factor TMZ 100 p-value
GS249 GBM 53 215 - / ND 0.30 0.66 3.06 0.01 2.92 0.03
GS187 GBM 73 394 - / UM 0.12 0.55 2.22 0.00 2.31 0
GS41 AOD 64 1316 ND 0.11 0.61 1.74 0.08 0.92 0.19
GS125 GBM 75 234 + / UM 0.21 0.71 1.59 0.17 1.78 0.06
GS203 GBM 64 554 - / M 0.39 0.61 1.68 0.01 1.71 0.01
GS184 GBM 50 833 - / M 0.16 0.74 1.40 0.10 1.66 0.01
GS186 GBM 49 792 - / M 0.21 0.74 1.30 0.03 1.49 0
GS224 GBM 58 101 - / M 0.17 0.73 1.15 0.20 1.20 0.03
GS177 GBM 63 843 - / M 0.20 0.76 1.14 0.01 1.15 0.2
GS182 GBM 70 835 - / M 0.38 0.51 1.14 0.02 1.31 0.05
GS200 GBM 57 321 - / ND 0.48 0.35 1.16 0.02 1.18 0.08
GS143 GBM 54 395 - / ND 0.60 0.32 1.17 0.40 1.32 0.09
GS126 GBM 41 962 + / M 0.27 0.06 1.68 0.02 1.69 0.01
GS79 GBM 71 384 + / UM 0.11 0.23 2.11 0.00 2.48 0
GS124 GBM 71 1033 + / ND 0.22 −0.11 1.19 0.40 1.19 0.06
GS148 AOD 82 97 + / UM 0.20 −0.07 1.15 0.80 1.15 0.06
GS173 GBM 68 138 + / ND −0.05 0.14 1.24 0.07 1.73 0.01
GS204 GBM 50 18 + / UM 0.07 0.02 1.17 0.03 1.17 0.04
GS161 GBM 62 264 + / M 0.17 −0.02 0.80 0.04 0.80 0.2
GS160 GBM 46 46 + / UM 0.07 0.16 0.83 0.03 0.75 0
  1. The separation between TMZ sensitive and resistant groups is based on monotherapy results for TMZ 100 μM results. Significance is depicted as a p-value derived Student’s T-test of the most effective single agent compared to combination therapy. For OS, boxes without shading depict patients that were alive at the moment of composing this article. Abbreviations as followed; AOD = Anaplastic Oligodendroglioma, GBM = Glioblastoma Multiforme, OS = Overall Survival in days, MGMT = O6-methylguanine-DNA methyltransferase, Blot = Western blotting results which can be positive (+) or negatieve (−), Methyl = Methylation assay which can be Methylated or UnMethylated). ND = Not determined.