Effect of CLE on weekly fasting blood glucose (A), and oral glucose (B) and intraperitoneal insulin (C) tolerance test in db/db mice. For glucose and insulin tolerance tests, after 12 h of fasting, mice were given glucose (2 g/kg body weight) for OGTT and insulin (2 units/kg body weight) for IPITT. The blood glucose level was measured at the indicated times and is presented as mmol/L. Each value represents the mean ± SE, n = 7 mice. ##
p < 0.01, control group versus normal group; *
p < 0.05 and **
p < 0.01, control group versus sample treated groups. CLE-250, db/db mice treated with C. lentillifera extract at 250 mg/kg body weight, CLE-500, db/db mice treated with C. lentillifera extract at 500 mg/kg body weight, RSG-10, db/db mice treated with rosiglitazone at 10 mg/kg body weight.