Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model

Table 3 The association between patients’ pathological data and inflammatory biomarkers

Variables	Tumor grade ^a		P *	Tumor stage ^b		P *	Depth of invasion		P *	Lymph node		P *	Distant metastasis		P *
Variables	G1-G2	G3-G4	P *	I-II	III-IV	P *	T1-T2	T3-T4	P *	N0	N1-N3	P *	M0	M1	P *
NLR	6.51 ± 10.79	5.64 ± 6.81	0.512	4.73 ± 6.73	7.07 ± 10.50	0.000	4.02 ± 6.67	6.54 ± 9.60	0.000	4.81 ± 8.03	6.41 ± 9.45	0.000	5.00 ± 7.92	7.82 ± 10.70	0.000
dNLR	4.08 ± 5.94	3.51 ± 3.61	0.516	3.13 ± 3.63	4.31 ± 5.76	0.000	2.67 ± 3.24	4.06 ± 5.29	0.000	3.01 ± 3.92	4.01 ± 5.23	0.000	3.32 ± 4.51	4.61 ± 5.65	0.013
PLR	210 ± 248	169 ± 103	0.185	170 ± 121	207 ± 235	0.010	146 ± 135	201 ± 206	0.039	160 ± 137	199 ± 208	0.001	170 ± 122	225 ± 272	0.001
LMR	4.65 ± 3.73	4.95 ± 5.83	0.808	5.74 ± 5.93	4.13 ± 3.66	0.001	6.90 ± 8.55	4.36 ± 3.42	0.000	6.71 ± 8.31	4.35 ± 3.40	0.000	5.70 ± 5.79	3.39 ± 1.88	0.000

NLR, neutrophil count to lymphocyte count; dNLR, neutrophil count to (white cell count – neutrophil count); PLR, platelet count to lymphocyte count; LMR, lymphocyte to monocyte ratio
*Difference between groups was tested by Mann–Whitney U or Kruskal-Wallis test.
^aGrade 1 and 2 stand for high or middle differentiated tumor, grade 3 and 4 stand for poorly differentiated tumor.
^bTumor stage according to seventh edition of American Joint of Committee on Cancer.

ISSN: 1479-5876