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Table 1 Patient demographics and clinical characteristics

From: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib

Parameter

No.

Sex

 

Male

22

Female

15

Median age, years

58

Range

27-77

ECOG performance status

 

0

20

1

17

Tumor biopsy sites

 

Liver

15

Abdominal wall

9

Rectum/vaginal wall

4

Scalp

2

Lymph node

5

Prior lines of treatment

 

2-3

18 (51%)

≥4

17 (49%)

Prior treatment

 

Bevacizumab

15 (43%)

Cetuximab

15 (43%)

Baseline organ function

 

AST (U/L)

34.6 ± 22.4

ALT (U/L)

23.5 ± 10.9

Total bilirubin (μmol/L)

10.1 ± 5.8

Creatinine (μmol/L)

66.9 ± 27.0

  1. 37 patients screened; 35 commenced therapy, 2 failed screening.
  2. 8 patients did not complete cycle 2 for tumour biopsy and evaluation of response.
  3. 11 patients did not have second biopsy.