From: Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure
Characteristic | GRK5 Gln41Gln (n = 1681) | GRK5 Gln41Leu (n = 26) | P value | ADRB1 Arg389Arg (n = 907) | ADRB1 Arg389Gly (n = 749) | ADRB1 Arg389Gly (n = 129) | P value |
---|---|---|---|---|---|---|---|
Age, yrs | 58.70 ± 11.34 | 59.12 ± 9.62 | 0.852 | 58.71 ± 11.20 | 58.84 ± 11.38 | 56.61 ± 11.99 | 0.114 |
Male gender, % | 35.7 | 50.0 | 0.131 | 37.2 | 34.7 | 47.3 | 0.023 |
Weight, kg | 62.78 ± 11.04 | 66.24 ± 8.93 | 0.119 | 63.12 ± 10.84 | 62.60 ± 11.59 | 63.50 ± 9.76 | 0.528 |
Height, cm | 161.24 ± 7.92 | 161.50 ± 8.56 | 0.868 | 161.77 ± 7.75 | 160.82 ± 7.92 | 163.35 ± 8.27 | 0.001 |
Systolic BP, mmHg | 133.36 ± 22.43 | 137.88 ± 17.93 | 0.316 | 133.56 ± 23.67 | 132.95 ± 20.41 | 132.04 ± 21.14 | 0.711 |
Diastolic BP, mmHg | 75.71 ± 11.79 | 79.04 ± 10.96 | 0.161 | 75.89 ± 11.83 | 75.51 ± 11.64 | 74.75 ± 11.09 | 0.543 |
Heart rate, beats/min | 74.45 ± 11.38 | 79.29 ± 12.51 | 0.039 | 74.00 ± 10.53 | 75.06 ± 11.42 | 71.28 ± 13.90 | 0.002 |
Smoking, % | 23.6 | 30.8 | 0.393 | 23.7 | 22.1 | 29.2 | 0.199 |
Drinking, % | 14.2 | 19.2 | 0.467 | 13.7 | 14.2 | 20.8 | 0.099 |
Hypertension, % | 39.4 | 53.8 | 0.136 | 38.8 | 39.9 | 35.4 | 0.614 |
CAD, % | 9.3 | 7.7 | 0.776 | 9.5 | 9.0 | 5.0 | 0.470 |
Diabetes mellitus, % | 11.5 | 15.4 | 0.542 | 11.9 | 11.0 | 8.5 | 0.496 |
SHF, % | 13.8 | 15.4 | 0.817 | 13.3 | 13.9 | 10.0 | 0.490 |
Medication, n (%) | Â | Â | Â | Â | Â | Â | Â |
 ACE inhibitors | 62 (3.7) | 2 (7.7) | 0.254 | 35 (3.8) | 22 (2.9) | 8 (6.2) | 0.174 |
 Angiotensin receptor blockers | 156 (9.3) | 3 (11.5) | 0.729 | 69 (7.6) | 69 (9.2) | 12 (8.0) | 0.456 |
 Beta-blockers | 122 (7.3) | 5 (19.2) | 0.039 | 58 (6.4) | 61 (8.1) | 5 (3.8) | 0.132 |
 Aldosterone antagonists | 142 (8.4) | 2 (7.7) | 1.000 | 69 (7.6) | 67 (9.0) | 9 (6.9) | 0.520 |
 Diuretics | 176 (10.5) | 2 (7.7) | 1.000 | 89 (9.8) | 79 (10.6) | 12 (9.2) | 0.825 |
 Digoxin | 60 (3.6) | 0 | 1.000 | 36 (4.0) | 20 (2.7) | 4 (3.1) | 0.347 |
Echocardiography | Â | Â | Â | Â | Â | Â | Â |
 LAD, mm | 35.58 ± 6.78 | 34.58 ± 4.21 | 0.474 | 35.63 ± 7.09 | 35.37 ± 6.32 | 35.84 ± 5.89 | 0.660 |
 LVESD, mm | 30.68 ± 7.41 | 29.54 ± 3.32 | 0.451 | 30.75 ± 7.78 | 30.25 ± 6.76 | 30.77 ± 6.60 | 0.383 |
 LVEDD, mm | 47.61 ± 6.40 | 47.29 ± 4.56 | 0.805 | 47.86 ± 6.62 | 47.39 ± 6.02 | 48.47 ± 5.66 | 0.126 |
 LVEF, % | 61.51 ± 9.46 | 62.68 ± 7.40 | 0.540 | 61.80 ± 9.37 | 61.64 ± 9.22 | 61.62 ± 10.22 | 0.941 |
Laboratory | Â | Â | Â | Â | Â | Â | Â |
 Total cholesterol, mmol/l | 5.02 ± 1.15 | 4.73 ± 1.21 | 0.198 | 5.00 ± 1.09 | 5.04 ± 1.23 | 4.84 ± 1.05 | 0.172 |
 LDL-C, mmol/l | 3.03 ± 1.10 | 2.90 ± 0.88 | 0.539 | 3.04 ± 1.06 | 3.02 ± 0.90 | 2.85 ± 0.74 | 0.190 |
 HDL-C, mmol/l | 1.29 ± 0.34 | 1.19 ± 0.31 | 0.127 | 1.27 ± 0.35 | 1.31 ± 0.34 | 1.26 ± 0.32 | 0.351 |
 Triglyceride, mmol/l | 1.41 [1.00, 2.01] | 1.64 [1.67, 2.19] | 0.838 | 1.40[0.99, 2.00] | 1.39 [1.01, 2.00] | 1.41 [1.00, 2.01] | 0.988 |
 Glycosylated hemoglobin, % | 5.80 [5.50, 6.20] | 5.70 [5.38, 6.25] | 0.623 | 5.70 [5.50, 6.20] | 5.80 [5.50, 6.20] | 5.64 [5.40, 6.00] | 0.041 |
 Creatinine, umol/l | 73.46 ± 25.31 | 78.20 ± 15.35 | 0.351 | 73.20 ± 22.38 | 74.12 ± 28.14 | 72.54 ± 21.80 | 0.678 |
 eGFR, ml/min/1.73 m2 | 97.56 | 86.26 | 0.078 | 98.38 | 96.47 | 99.47 | 0.209 |
 Median (Q1,Q3) | [83.59, 113.45] | [76.26, 112.03] |  | [83.13, 113.22] | [82.18, 113.32] | [86.83, 119.79] |  |
 Plasma NT-proBNP, pg/ml | 52.00 | 45.00 | 0.867 | 53.00 | 51.00 | 55.00 | 0.926 |
 Median (Q1,Q3) | [30.00, 87.00] | [33.00, 102.00] |  | [30.00, 87.00] | [29.00, 91.00] | [28.00, 103.00] |  |