Table 3 Consistency between BRAF/NRAS/PIK3CA mutations in multiple melanomas from same patients, and mutation patterns in those in whom there were discrepancies
From: Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas
No. of cases | Cases with consistent mutation patterns (second vs first tumor sample), n (%) | Mutation patterns among discrepant paired samples | |||||
|---|---|---|---|---|---|---|---|
BRAF | NRAS | PIK3CA | |||||
First tumor | Second tumor | First tumor | Second tumor | First tumor | Second tumor | ||
26 | 14 (53.8) | wt | V600E | wt | wt | wt | wt |
| Â | wt | wt | wt | wt | wt | E545A | |
V600E | wt | wt | Q61R | E545A | wt | ||
V600K | wt | wt | wt | wt | wt | ||
wt | wt | wt | wt | E545A | wt | ||
V600E | wt | wt | wt | wt | wt | ||
wt | wt | wt | wt | wt | E542K | ||
V600E | wt | wt | wt | wt | wt | ||
V600E | wt | wt | wt | wt | wt | ||
wt | wt | Q61R | wt | wt | wt | ||
wt | V600E | wt | wt | E545G | wt | ||
wt | V600E | wt | wt | wt | wt | ||